By Andreas-Holger Maehle, Cay-Rüdiger Prüll, Robert Francis Halliwell
The receptor proposal was once the most influential principles in 20th-century medication since it may possibly account for the hugely particular results of substances at the physique. This ebook is the 1st to supply an ancient dialogue of its beginning, improvement, gradual attractiveness into pharmacology and next effect on glossy medication. It additionally considers the social context that motivated the drug receptor's development., creating a helpful contribution to the background and knowing of contemporary drugs.
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Extra resources for A Short History of the Drug Receptor Concept (Science, Technology and Medicine in Modern History)
He turned to immunological work. 53 In 1890, only one year later, the period of private science ended when Robert Koch offered his former helper a post as clinical supervisor for scientific studies on tuberculosis at the City Hospital Berlin-Moabit. Now Ehrlich was able to take up clinical experimentation again, as he had done during his time with Frerichs, and he again combined Paul Ehrlich and his Receptor Concept 25 it with animal experimentation and histological investigations in the laboratory.
151 Ehrlich’s receptor concept was basic research, hard to understand, and the technical possibilities of his times were restricted. But there are further reasons: despite his reputation, Ehrlich was no pharmacologist and he deviated from the mainstream of contemporary pharmacology research. 152 Above all, the doubts of contemporary pharmacologists were fuelled by the hypothetical character of Ehrlich’s theory,153 which could be pushed forward only with a vast propaganda apparatus. 155 As a construction which came into existence as a product of Ehrlich’s social biography, personality 40 A Short History of the Drug Receptor Concept and scientific career development, the receptors were the final stage of a process spiralling up into the enterprise of theoretical research.
Arrhenius and Madsen applied basic chemical laws to processes of life, which according to Ehrlich, could not be expressed in such rigid formulas. 114 This was of course, an exaggeration. Physico-chemical explanations gained ground in the following decades, but this outcome was hard to foresee during the first years of the twentieth century, when there was no generally accepted drug binding theory and different scientists worked to promote their own approaches. Even more serious was Ehrlich’s dispute with Max (von) Gruber (1853–1927), professor of hygiene in Vienna from 1887 to 1902 and in Munich from 1902 to 1923.
A Short History of the Drug Receptor Concept (Science, Technology and Medicine in Modern History) by Andreas-Holger Maehle, Cay-Rüdiger Prüll, Robert Francis Halliwell