By Birendra N. Pramanik, A.K. Ganguly, Michael L. Gross
Discussing innovations to figure out the constitution and machanisms of diverse compound classics, this ebook covers new chemical and elctrophoretic thoughts for quick pattern preconcentration and separation. It summarizes breakthroughs within the conception and instrumentation of electrospray mass spectrometry in pharmaceutical and biomedical functions, offers functional examples for the characterization of peptides, proteins, and glycoproteins, contains functions in proteomics, combinatorial chemistry, and drug characterization. themes contain chemical and electrophoretic strategies for fast pattern preconcentration and separation, screening approaches for proteins from libraries of compounds, protein folding and dynamics, and extra
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Extra resources for Applied Electrospray Mass Spectrometry: Practical Spectroscopy Series Volume 32
Although true tandem mass spectrometry (MS/MS) is not available with single-quadrupole mass spectrometers, in-source CID can provide some MS/MS functionality by providing a method for inducing fragmentation (341). Copyright © 2002 by Taylor & Francis In-source CID does not provide any precursor ion selectivity, and product ions will be observed for background contaminants and coeluting species as well as for the analyte. If one needs MS/MS capabilities for structural analysis or for improving target compound selectivity by selected reaction monitoring, a triple-stage quadrupole mass spectrometer (TQMS) must be used.
Postcolumn addition of a suitable solvent may be considered if it is necessary to interface normal-phase LC with an ESI source. To further complicate the choice, the reader is reminded that other sample introduction methods (such as GC/MS) and ionization methods (such as MALDI) may be just as good as, or better than, ESI or APCI for a given analysis. The detection limits for electron ionization mass spectrometry or electron Copyright © 2002 by Taylor & Francis capture negative ion mass spectrometry can be in the low femtogram range.
FTICR. Fourier transform ion cyclotron resonance mass spectrometry (FTICR or FTMS) has provided some of the most creative and spectacular research related to electrospray ionization, and the number of publications on ESI/FTICR fundamentals and applications is worthy of a separate review. Several summaries have been published describing of the state of the art in FTICR analysis of large biomolecules. First reported in 1989 in a collaborative effort between researchers in McLafferty’s group at Cornell and Hunt’s group at the University of Virginia (158), the ESI/FTICR combination is a particularly good match between the strengths of the source and the analyzer (355).
Applied Electrospray Mass Spectrometry: Practical Spectroscopy Series Volume 32 by Birendra N. Pramanik, A.K. Ganguly, Michael L. Gross