By Balaban A.T., Oniciu D.C., Katritzky A,R.
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Additional info for Aromaticity as a Cornerstone of Heterocyclic Chemistry
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Table 5. Theoretical Possibilities for Cycl[a,b,c]azines with 9 e m e 12 natural alkaloids and of medicinal drugs contain heteroaromatic groups. Combinatorial chemistry and high-throughput screening are focused on druglike molecules that are predominantly heteroaromatic. Heterocyclic chemistry offers a much wider prospect for exploring the possibilities and limitations of the aromaticity concept than hydrocarbon chemistry. As a result, quantitative measures for aromaticity have been devised, and improved molecular calculation methods allow for a better evaluation of the experimental data already obtained and predictions of novel aromatic heterocycles.
Aromaticity as a Cornerstone of Heterocyclic Chemistry by Balaban A.T., Oniciu D.C., Katritzky A,R.