Bacterial and Eukaryotic Porins: Structure, Function, by Roland Benz PDF

By Roland Benz

ISBN-10: 3527307753

ISBN-13: 9783527307753

ISBN-10: 3527604227

ISBN-13: 9783527604227

This primary booklet devoted to the subject relates the identified physiological services of porins to their molecular constitution and mechanism, as documented by means of numerous in vitro and in vivo equipment, together with the new release of null mutants in mice. For the 1st time, it brings jointly biophysical facts with reports played in a mobile context, proposing a unified photograph of the elemental value of porins for mobile functionality. With sixteen contributions via an interdisciplinary workforce of best porin researchers, this reference is key interpreting for each molecular or structural biologist with an curiosity during this crucial protein kin.

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Extra info for Bacterial and Eukaryotic Porins: Structure, Function, Mechanism

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Therefore, its interface to the membrane caught particular attention. The expected ribbon of non-polar residues was readily detected. 3. Interestingly, the ribbon splits into three parts, an aliphatic central ribbon surrounding the trimer and two girdles of aromatic residues lining the ribbon on both sides [33, 34]. The width of the non-polar ribbon facing the non-polar membrane layer is only 20–25 â, which approximates the length of a single fatty acid chain. This is only half the thickness displayed in the textbooks which commonly show two opposing extended fatty acid chains forming the membrane.

Inouye, M. J Biol Chem 2002, 277, 24155–24161. , Goulian, M. Proc Natl Acad Sci USA 2003, 100, 691–696. , Forst, S. Mol Microbiol 1995, 17, 643–652. Leonardo, M. , Forst, S. Mol Microbiol 1996, 22, 405–413. , Silhavy, T. J. J Mol Biol 1989, 210, 291–292. , Inouye, M. J Bacteriol 1990, 172, 3473– 3477. Lukat, G. , McCleary, W. , Stock, A. , Stock, J. B. Proc Natl Acad Sci USA 1992, 89, 718–722. McCleary, W. , Stock, J. B. J Biol Chem 1994, 269, 31567–31572. , Mizuno, T. Biosci Biotechnol Biochem 1999, 63, 408–414.

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Bacterial and Eukaryotic Porins: Structure, Function, Mechanism by Roland Benz

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