By Lesley-Ann Giddings, David J. Newman
This SpringerBrief sheds new mild on bioactive fabrics from marine extremophiles. It bargains with all features of the chemical substances produced by way of organisms residing less than severe stipulations which may have strength as medicines or bring about novel medicinal drugs for human use.
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Extra info for Bioactive Compounds from Marine Extremophiles
Strains from the genera Thraustochytrium, Porphyridium, Nitzschia, Schizochytrium, Phaeodactylum, and Nannochloropsis have been reported to produce large quantities of PUFAs, and by varying the growth conditions, different ratios of ω-3 PUFAs can be obtained (Adarme-Vega et al. 2014). Furthermore, extensive research has been done on metabolically engineering biosynthetic genes in microalgae and other organisms, such as yeast (Xue et al. 2013), to produce greater yields of ω-3 PUFAs (Vaezi et al.
2003). Compound 107 and its cis-isomer 111 were determined to have similar antifungal activity against the fungus Phytophthora capsici, demonstrating that solely the β-methoxyacrylate moiety and not the stereochemistry of the substituents on the epoxide ring is required for bioactivity. The bioactivity of haliangicins B–D (108–110) could not be determined due to difﬁculties with their isolation. With pure compounds, the importance of their three stereogenic centers for bioactivity can be conﬁrmed.
Marinomycin C Fig. 7 Structures 121–129 reported to produce the only known triazolopyrimidine, essramycin 123 (Fig. 7), which has an unprecedented skeleton for a natural product (El-Gendy et al. 2008). Other 1,2,4-triazolo[1,5-a]pyrimidines have been synthesized and are used pharmaceutical agents, such as vasodilators and herbicides (Fischer 2007). Compound 123 exhibited potent antimicrobial activity against Gram-positive and Gram-negative bacteria. 5 µg/ml), S. aureus ATCC 6538 (MIC, 1 µg/ml), B.
Bioactive Compounds from Marine Extremophiles by Lesley-Ann Giddings, David J. Newman