By Lesley-Ann Giddings, David J. Newman
This SpringerBrief sheds new gentle on bioactive fabrics from marine extremophiles. It bargains with all features of the chemicals produced by way of organisms dwelling less than severe stipulations that can have power as medicines or result in novel medications for human use.
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Extra resources for Bioactive Compounds from Marine Extremophiles (SpringerBriefs in Microbiology / Extremophilic Bacteria)
Mediterranei to S. arenicola may have occurred at some point during its evolution. This is an excellent example of how ecological diversiﬁcation may have played a role in the unique enzymatic tailoring of natural products by a single cytochrome P450 enzyme encoded by biosynthetic pathway-speciﬁc genes in Salinispora sp. (Kim et al. 2006). With the S. arenicola CNS-205 genome available and chemical synthesis, additional modiﬁcations to the saliniketal core structure could possibly result in the production of more potent ornithine decarboxylase inhibitors or other bioactive metabolites.
01–100 µg/ ml. Of all thiomarinols, thiomarinol A 112 and thiomarinol B 113 exhibited the most potent antimicrobial activity. These compounds are almost structurally identical, with the exception of thiomarinol B 113 possessing a sulfoxide in the holothin moiety of the molecule, which does not appear to signiﬁcantly affect activity. The mode of action of compounds 112–113 and 115 is thought to occur via the inhibition of the isoleucyl-transfer RNA synthetase in eubacteria, which is a similar mode of action to that of pseudomonic acid A (a component of these molecules).
7 cells, the production of proinflammatory mediators, iNOS, NO production as a result of iNOS, and prostaglandin E2 was determined. 7 cells. Arenamides A and B (166–167) inhibited NO production by approximately 35 % in a dose-dependent manner without affecting cell viability as well as prostaglandin E2 production by approximately 50 %. These compounds may be useful in understanding the role of NFKB in the regulation of cell survival genes as well as the expression of iNOS and other enzyme mediators.
Bioactive Compounds from Marine Extremophiles (SpringerBriefs in Microbiology / Extremophilic Bacteria) by Lesley-Ann Giddings, David J. Newman