Download e-book for iPad: Biological Basis of Alcohol-Induced Cancer by Vasilis Vasiliou, Samir Zakhari, Helmut K. Seitz, Jan B.

By Vasilis Vasiliou, Samir Zakhari, Helmut K. Seitz, Jan B. Hoek

ISBN-10: 3319096133

ISBN-13: 9783319096131

ISBN-10: 3319096141

ISBN-13: 9783319096148

In the new years, an important quantity of analysis has emerged connecting the hyperlink among alcohol and melanoma. the sector has quickly complicated, in particular because the complicated connection among alcohol and melanoma has numerous targeted sub parts which are being investigated. This lawsuits quantity will comprise chapters dependent upon the presentation of the 2d foreign convention on Alcohol and melanoma in Colorado, 2013. some of the issues discover the impacts of alcohol on: liver and breast melanoma; mobilephone signaling and melanoma; stem cells; biomarkers and metabolomics; aerodigestive cancers; melanoma and the immune method and more.

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Additional info for Biological Basis of Alcohol-Induced Cancer

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The Million Women Study [26] conducted in the United Kingdom and published in 2009 calculated the RR for 21 site-specific cancers due to beverage alcohol consumption, including breast cancer, based on a questionnaire asking about the average alcohol consumption per week. Of the 1,280,296 women recruited, data from 708,265 women from a follow-up survey three years later were used. The study reported that women who drank alcohol were “likely to be younger, leaner, more affluent, and to do strenuous exercise more frequently” and more likely to “have ever used oral contraceptives and to be currently using hormone replacement therapy” than nondrinkers.

5 years, these animals were given alcohol solution as the only drink available for about as much as 85 % of their life, at a rate equivalent to nonstop binge drinking, a situation that is neither physiological nor normal for humans. Another study used transgenic mice that overexpress the HER2 protein (encoded by the proto-oncogene HER2⁄neu) in the mammary epithelium, resulting in the development of estrogen receptor alpha (ERα)-negative mammary tumors, similar to those of patients with HER2+ breast cancer [61].

1 % of that in the liver. In humans, studies on normal and neoplastic breast tissue showed that class I, but not class IV, ADH is expressed in human mammary epithelium, which can support ADH-mediated oxidation of ethanol; however, the expression of class I ADH is dramatically reduced or abrogated in invasive breast cancers [77]. ” However, whether the reduction in class I ADH activity was causally related to tumor formation or was merely a bystander effect was not considered. 8 mL ethanol/kg/day for four consecutive days [78].

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Biological Basis of Alcohol-Induced Cancer by Vasilis Vasiliou, Samir Zakhari, Helmut K. Seitz, Jan B. Hoek

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